Orthotopic and heterotopic murine models of pancreatic cancer and their different responses to FOLFIRINOX chemotherapy

Orthotopic and heterotopic murine models of pancreatic cancer and their different responses to FOLFIRINOX chemotherapy

Syngeneic, immunocompetent allograft tumor models recapitulate important aspects of the tumor microenvironment and have short tumor latency with predictable growth kinetics, making them useful for trialing novel therapeutics. Here, we describe surgical techniques for orthotopic and heterotopic pancr...

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Bibliographic Details
Main Authors: Derek J. Erstad, Mozhdeh Sojoodi, Martin S. Taylor, Sarani Ghoshal, Allen A. Razavi, Katherine A. Graham-O'Regan, Nabeel Bardeesy, Cristina R. Ferrone, Michael Lanuti, Peter Caravan, Kenneth K. Tanabe, Bryan C. Fuchs
Format: Article
Language:English
Published: The Company of Biologists 2018-07-01
Series:Disease Models & Mechanisms
Subjects:
PDAC animal model
Surgical technique
Chemoresistance
Orthotopic
Heterotopic
Online Access:http://dmm.biologists.org/content/11/7/dmm034793

Internet

http://dmm.biologists.org/content/11/7/dmm034793

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