The Extent of Intracellular Accumulation of Bilirubin Determines Its Anti- or Pro-Oxidant Effect

The Extent of Intracellular Accumulation of Bilirubin Determines Its Anti- or Pro-Oxidant Effect

Background: Severe hyperbilirubinemia can cause permanent neurological damage in particular in neonates, whereas mildly elevated serum bilirubin protects from various oxidative stress-mediated diseases. The present work aimed to establish the intracellular unconjugated bilirubin concentrations (iUCB...

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Bibliographic Details
Main Authors: Annalisa Bianco, Aleš Dvořák, Nikola Capková, Camille Gironde, Claudio Tiribelli, Christophe Furger, Libor Vitek, Cristina Bellarosa
Format: Article
Language:English
Published: MDPI AG 2020-10-01
Series:International Journal of Molecular Sciences
Subjects:
bilirubin
ROS
antioxidant
redox state
bilirubin neurotoxicity
Online Access:https://www.mdpi.com/1422-0067/21/21/8101

Internet

https://www.mdpi.com/1422-0067/21/21/8101

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