Dissociation of Fatty Liver and Insulin Resistance in I148M PNPLA3 Carriers: Differences in Diacylglycerol (DAG) FA18:1 Lipid Species as a Possible Explanation

Dissociation of Fatty Liver and Insulin Resistance in I148M PNPLA3 Carriers: Differences in Diacylglycerol (DAG) FA18:1 Lipid Species as a Possible Explanation

Fatty liver is tightly associated with insulin resistance and the development of type 2 diabetes. I148M variant in patatin-like phospholipase domain-containing protein 3 (PNPLA3) gene is associated with high liver fat but normal insulin sensitivity. The underlying mechanism of the disassociation bet...

Full description

Bibliographic Details
Main Authors: Andras Franko, Dietrich Merkel, Marketa Kovarova, Miriam Hoene, Benjamin A. Jaghutriz, Martin Heni, Alfred Königsrainer, Cyrus Papan, Stefan Lehr, Hans-Ulrich Häring, Andreas Peter
Format: Article
Language:English
Published: MDPI AG 2018-09-01
Series:Nutrients
Subjects:
NAFLD
liver
PNPLA3
diacylglycerol
lipidomics
Online Access:http://www.mdpi.com/2072-6643/10/9/1314

Internet

http://www.mdpi.com/2072-6643/10/9/1314

Similar Items