The Aβ Containing Brain Extracts Having Different Effects in Alzheimer’s Disease Transgenic Caenorhabditis elegans and Mice

The Aβ Containing Brain Extracts Having Different Effects in Alzheimer’s Disease Transgenic Caenorhabditis elegans and Mice

Background: The deposition of β-sheet rich amyloid in senile plaques is a pathological hallmark of Alzheimer’s disease (AD), which is thought to cause neuronal dysfunction. Previous studies have strongly implicated that intracerebral infusion of brain extract containing aggregated β-amyloid (Aβ) is...

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Bibliographic Details
Main Authors: Yufang Yang, Mo Wang, Ping Yang, Zishan Wang, Li Huang, Jing Xu, Wei Wang, Mei Yu, Liping Bu, Jian Fei, Fang Huang
Format: Article
Language:English
Published: Frontiers Media S.A. 2018-07-01
Series:Frontiers in Aging Neuroscience
Subjects:
Alzheimer’s disease
β-amyloid
transgenic AD C. elegans
APP/PS1 transgenic mice
oral administration
RNA-sequencing (RNA-seq)
Online Access:https://www.frontiersin.org/article/10.3389/fnagi.2018.00208/full

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https://www.frontiersin.org/article/10.3389/fnagi.2018.00208/full

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