Deficiency in STAT1 Signaling Predisposes Gut Inflammation and Prompts Colorectal Cancer Development

Deficiency in STAT1 Signaling Predisposes Gut Inflammation and Prompts Colorectal Cancer Development

Signal transducer and activator of transcription 1 (STAT1) is part of the Janus kinase (JAK/STAT) signaling pathway that controls critical events in intestinal immune function related to innate and adaptive immunity. Recent studies have implicated STAT1 in tumor–stroma interactions, and its expressi...

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Bibliographic Details
Main Authors: Sonia Leon-Cabrera, Armando Vázquez-Sandoval, Emmanuel Molina-Guzman, Yael Delgado-Ramirez, Norma L. Delgado-Buenrostro, Blanca E. Callejas, Yolanda I. Chirino, Carlos Pérez-Plasencia, Miriam Rodríguez-Sosa, Jonadab E. Olguín, Citlaltepetl Salinas, Abhay R. Satoskar, Luis I. Terrazas
Format: Article
Language:English
Published: MDPI AG 2018-09-01
Series:Cancers
Subjects:
colorectal cancer
STAT1
inflammation
Online Access:http://www.mdpi.com/2072-6694/10/9/341

Internet

http://www.mdpi.com/2072-6694/10/9/341

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