Can acetylcysteine ameliorate cisplatin‐induced toxicities and oxidative stress without decreasing antitumor efficacy? A randomized, double‐blind, placebo‐controlled trial involving patients with head and neck cancer

Can acetylcysteine ameliorate cisplatin‐induced toxicities and oxidative stress without decreasing antitumor efficacy? A randomized, double‐blind, placebo‐controlled trial involving patients with head and neck cancer

Abstract The protective antioxidant activity of acetylcysteine (NAC) against toxicity due to cisplatin has been reported in experimental models; however, its efficacy in patients has not been elucidated. The aim of this study was to investigate the possible protective effect of NAC on cisplatin‐indu...

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Bibliographic Details
Main Authors: Marília B. Visacri, Júlia C. F. Quintanilha, Vanessa M. deSousa, Laís S. Amaral, Rosiane de F. L.Ambrósio, Luciane Calonga, Silvia F. B. B. Curi, Mayra F. de T.Leme, Carlos T. Chone, João M. C. Altemani, Priscila G. Mazzola, Carina Malaguti, Aníbal E. Vercesi, Carmen S. P. Lima, Patricia Moriel
Format: Article
Language:English
Published: Wiley 2019-05-01
Series:Cancer Medicine
Subjects:
acetylcysteine
cisplatin
head and neck neoplasms
oxidative stress
toxicities
Online Access:https://doi.org/10.1002/cam4.2072

Internet

https://doi.org/10.1002/cam4.2072

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