Direct Delivery of piggyBac CD19 CAR T Cells Has Potent Anti-tumor Activity against ALL Cells in CNS in a Xenograft Mouse Model

Direct Delivery of piggyBac CD19 CAR T Cells Has Potent Anti-tumor Activity against ALL Cells in CNS in a Xenograft Mouse Model

The anti-CD19 chimeric antigen receptor (CAR) T cells showed excellent effect against acute lymphoblastic leukemia (ALL) in bone marrow (BM) in clinical trials. However, it remains to be elucidated whether the CD19 CAR T cell therapy is effective for ALL cells in central nervous system (CNS) because...

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Bibliographic Details
Main Authors: Kuniaki Tanaka, Itaru Kato, Miyuki Tanaka, Daisuke Morita, Kazuyuki Matsuda, Yoshiyuki Takahashi, Tatsutoshi Nakahata, Katsutsugu Umeda, Hidefumi Hiramatsu, Souichi Adachi, Junko Takita, Yozo Nakazawa
Format: Article
Language:English
Published: Elsevier 2020-09-01
Series:Molecular Therapy: Oncolytics
Subjects:
CNS-ALL
xenograft mouse model
piggyBac transposon
CD19 CAR T cells
intra thecal delivery
intra-cerebroventricular
Online Access:http://www.sciencedirect.com/science/article/pii/S2372770520300760

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http://www.sciencedirect.com/science/article/pii/S2372770520300760

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