Microglial Hyperreactivity Evolved to Immunosuppression in the Hippocampus of a Mouse Model of Accelerated Aging and Alzheimer’s Disease Traits

Microglial Hyperreactivity Evolved to Immunosuppression in the Hippocampus of a Mouse Model of Accelerated Aging and Alzheimer’s Disease Traits

Neuroinflammation is a risk factor for Alzheimer’s disease (AD). We sought to study the glial derangement in AD using diverse experimental models and human brain tissue. Besides classical pro-inflammatory cytokines, we analyzed chitinase 3 like 1 (CHI3L1 or YKL40) and triggering receptor expressed o...

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Bibliographic Details
Main Authors: Patricia Molina-Martínez, Rubén Corpas, Elisa García-Lara, Marta Cosín-Tomás, Rosa Cristòfol, Perla Kaliman, Carme Solà, José Luis Molinuevo, Raquel Sánchez-Valle, Anna Antonell, Albert Lladó, Coral Sanfeliu
Format: Article
Language:English
Published: Frontiers Media S.A. 2021-01-01
Series:Frontiers in Aging Neuroscience
Subjects:
neuroinflammation
SAMP8 mice
autosomal dominant Alzheimer’s disease (ADAD)
sporadic early-onset Alzheimer’s disease (sEOAD)
triggering receptor expressed on myeloid cells 2 (TREM2)
Online Access:https://www.frontiersin.org/articles/10.3389/fnagi.2020.622360/full

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https://www.frontiersin.org/articles/10.3389/fnagi.2020.622360/full

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