Susceptibility to Mycobacterium ulcerans Disease (Buruli ulcer) Is Associated with IFNG and iNOS Gene Polymorphisms

Susceptibility to Mycobacterium ulcerans Disease (Buruli ulcer) Is Associated with IFNG and iNOS Gene Polymorphisms

Buruli ulcer (BU) is a chronic necrotizing disease of the skin and subcutaneous fat tissue. The causative agent, Mycobacterium ulcerans, produces mycolactone, a macrolide toxin, which causes apoptosis of mammalian cells. Only a small proportion of individuals exposed to M. ulcerans develop clinical...

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Bibliographic Details
Main Authors: Stéphanie Bibert, Martin W. Bratschi, Samuel Y. Aboagye, Emilie Collinet, Nicole Scherr, Dorothy Yeboah-Manu, Christian Beuret, Gerd Pluschke, Pierre-Yves Bochud
Format: Article
Language:English
Published: Frontiers Media S.A. 2017-10-01
Series:Frontiers in Microbiology
Subjects:
immunogenetics
Buruli ulcer
Mycobacterium ulcerans
infectious diseases
single nucleotide polymorphism
Online Access:http://journal.frontiersin.org/article/10.3389/fmicb.2017.01903/full

Internet

http://journal.frontiersin.org/article/10.3389/fmicb.2017.01903/full

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