miR-181 regulates GRP78 and influences outcome from cerebral ischemia in vitro and in vivo

miR-181 regulates GRP78 and influences outcome from cerebral ischemia in vitro and in vivo

MicroRNAs (miRNA) are short (~22 nt) single stranded RNAs that downregulate gene expression. Although recent studies indicate extensive miRNA changes in response to ischemic brain injury, there is currently little information on the roles of specific miRNAs in this setting. Heat shock proteins (HSP)...

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Bibliographic Details
Main Authors: Yi-Bing Ouyang, Yu Lu, Sibiao Yue, Li-Jun Xu, Xiao-Xing Xiong, Robin E. White, Xiaoyun Sun, Rona G. Giffard
Format: Article
Language:English
Published: Elsevier 2012-01-01
Series:Neurobiology of Disease
Subjects:
MicroRNA
miR-181a
78 kDa glucose-regulated protein (GRP78/HSPA5/BiP)
Stroke
Heat shock protein
Translational regulation
Online Access:http://www.sciencedirect.com/science/article/pii/S0969996111003226

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http://www.sciencedirect.com/science/article/pii/S0969996111003226

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