Screening of benzenesulfonamide in combination with chemically diverse fragments against carbonic anhydrase by differential scanning fluorimetry

Screening of benzenesulfonamide in combination with chemically diverse fragments against carbonic anhydrase by differential scanning fluorimetry

The differential scanning fluorimetry (DSF) screening of 5.692 fragments in combination with benzenesulfonamide (BSA) against bovine carbonic anhydrase (bCA) delivered >100 hits that either caused, on their own, a significant thermal shift (ΔTm, °C) in the protein melting temperature or significa...

Full description

Bibliographic Details
Main Authors: Mikhail Krasavin, Stanislav Kalinin, Sergey Zozulya, Anastasiia Gryniukova, Petro Borysko, Andrea Angeli, Claudiu T. Supuran
Format: Article
Language:English
Published: Taylor & Francis Group 2020-01-01
Series:Journal of Enzyme Inhibition and Medicinal Chemistry
Subjects:
differential scanning fluorimetry
thermal shift assay
protein affinity
carbonic anhydrase ii
fragment-based drug discovery
primary sulphonamide
zinc binding group
Online Access:http://dx.doi.org/10.1080/14756366.2019.1698562

Internet

http://dx.doi.org/10.1080/14756366.2019.1698562

Similar Items