IFNγ induces epigenetic programming of human T-bethi B cells and promotes TLR7/8 and IL-21 induced differentiation

IFNγ induces epigenetic programming of human T-bethi B cells and promotes TLR7/8 and IL-21 induced differentiation

Although B cells expressing the IFNγR or the IFNγ-inducible transcription factor T-bet promote autoimmunity in Systemic Lupus Erythematosus (SLE)-prone mouse models, the role for IFNγ signaling in human antibody responses is unknown. We show that elevated levels of IFNγ in SLE patients correlate wit...

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Bibliographic Details
Main Authors: Esther Zumaquero, Sara L Stone, Christopher D Scharer, Scott A Jenks, Anoma Nellore, Betty Mousseau, Antonio Rosal-Vela, Davide Botta, John E Bradley, Wojciech Wojciechowski, Travis Ptacek, Maria I Danila, Jeffrey C Edberg, S Louis Bridges Jr, Robert P Kimberly, W Winn Chatham, Trenton R Schoeb, Alexander F Rosenberg, Jeremy M Boss, Ignacio Sanz, Frances E Lund
Format: Article
Language:English
Published: eLife Sciences Publications Ltd 2019-05-01
Series:eLife
Subjects:
interferons
B lymphocytes
antibody secreting cells
T-bet
systemic lupus erythematosus
Online Access:https://elifesciences.org/articles/41641

Internet

https://elifesciences.org/articles/41641

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