Physical interactions between MCM and Rad51 facilitate replication fork lesion bypass and ssDNA gap filling by non-recombinogenic functions

Physical interactions between MCM and Rad51 facilitate replication fork lesion bypass and ssDNA gap filling by non-recombinogenic functions

Summary: The minichromosome maintenance (MCM) helicase physically interacts with the recombination proteins Rad51 and Rad52 from yeast to human cells. We show, in Saccharomyces cerevisiae, that these interactions occur within a nuclease-insoluble scaffold enriched in replication/repair factors. Rad5...

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Bibliographic Details
Main Authors: María J. Cabello-Lobato, Cristina González-Garrido, María I. Cano-Linares, Ronald P. Wong, Aurora Yáñez-Vílchez, Macarena Morillo-Huesca, Juan M. Roldán-Romero, Marta Vicioso, Román González-Prieto, Helle D. Ulrich, Félix Prado
Format: Article
Language:English
Published: Elsevier 2021-07-01
Series:Cell Reports
Subjects:
DNA damage
MCM
Rad51
Rad52
Cdc7
homologous recombination
Online Access:http://www.sciencedirect.com/science/article/pii/S2211124721008573

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http://www.sciencedirect.com/science/article/pii/S2211124721008573

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