Immunization with SP_1992 (DiiA) Protein of <i>Streptococcus pneumoniae</i> Reduces Nasopharyngeal Colonization and Protects against Invasive Disease in Mice

Immunization with SP_1992 (DiiA) Protein of <i>Streptococcus pneumoniae</i> Reduces Nasopharyngeal Colonization and Protects against Invasive Disease in Mice

Knowledge-based vaccinology can reveal uncharacterized antigen candidates for a new generation of protein-based anti-pneumococcal vaccines. DiiA, encoded by the sp_1992 locus, is a surface protein containing either one or two repeats of a 37mer N-terminal motif that exhibits low interstrain variabil...

Full description

Bibliographic Details
Main Authors: Antonio J. Martín-Galiano, María S. Escolano-Martínez, Bruno Corsini, Adela G. de la Campa, José Yuste
Format: Article
Language:English
Published: MDPI AG 2021-02-01
Series:Vaccines
Subjects:
<i>Streptococcus pneumoniae</i>
reverse vaccinology
hypothetical protein
DiiA
sepsis
carrier state
Online Access:https://www.mdpi.com/2076-393X/9/3/187

Internet

https://www.mdpi.com/2076-393X/9/3/187

Similar Items