Role of Inactive and Active Trypanosoma cruzi Trans-sialidases on T Cell Homing and Secretion of Inflammatory Cytokines

Role of Inactive and Active Trypanosoma cruzi Trans-sialidases on T Cell Homing and Secretion of Inflammatory Cytokines

Trans-sialidase from Trypanosoma cruzi (Tc-TS) belongs to a superfamily of proteins that may have enzymatic activity. While enzymatically active members (Tc-aTS) are able to transfer sialic acid from the host cell sialyl-glycoconjugates onto the parasite or to other molecules on the host cell surfac...

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Bibliographic Details
Main Authors: Leonardo Freire-de-Lima, Luciana B. Gentile, Leonardo M. da Fonseca, Kelli M. da Costa, Jessica Santos Lemos, Lucas Rodrigues Jacques, Alexandre Morrot, Célio G. Freire-de-Lima, Marise P. Nunes, Christina M. Takiya, Jose O. Previato, Lucia Mendonça-Previato
Format: Article
Language:English
Published: Frontiers Media S.A. 2017-07-01
Series:Frontiers in Microbiology
Subjects:
Trypanosoma cruzi
trans-sialidase
T cells
sialic acid
cytokines
Online Access:http://journal.frontiersin.org/article/10.3389/fmicb.2017.01307/full

Internet

http://journal.frontiersin.org/article/10.3389/fmicb.2017.01307/full

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