Structure of Stem Cell Growth Factor R-spondin 1 in Complex with the Ectodomain of Its Receptor LGR5

Structure of Stem Cell Growth Factor R-spondin 1 in Complex with the Ectodomain of Its Receptor LGR5

Leucine-rich repeat-containing G protein-coupled receptors 4–6 (LGR4–LGR6) are receptors for R-spondins, potent Wnt agonists that exert profound trophic effects on Wnt-driven stem cells compartments. We present crystal structures of a signaling-competent fragment of R-spondin 1 (Rspo1) at a resolut...

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Bibliographic Details
Main Authors: Weng Chuan Peng, Wim de Lau, Federico Forneris, Joke C.M. Granneman, Meritxell Huch, Hans Clevers, Piet Gros
Format: Article
Language:English
Published: Elsevier 2013-06-01
Series:Cell Reports
Online Access:http://www.sciencedirect.com/science/article/pii/S2211124713002878

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http://www.sciencedirect.com/science/article/pii/S2211124713002878

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