Vitamin C supplementation expands the therapeutic window of BETi for triple negative breast cancerResearch in context

Vitamin C supplementation expands the therapeutic window of BETi for triple negative breast cancerResearch in context

Background: Bromodomain and extra-terminal inhibitors (BETi) have shown efficacy for the treatment of aggressive triple negative breast cancer (TNBC). However, BETi are plagued by a narrow therapeutic window as manifested by severe toxicities at effective doses. Therefore, it is a limitation to thei...

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Bibliographic Details
Main Authors: Sushmita Mustafi, Vladimir Camarena, Rehana Qureshi, Hyunho Yoon, Claude-Henry Volmar, Tyler C. Huff, David W. Sant, Lihong Zheng, Shaun P. Brothers, Claes Wahlestedt, Joyce Slingerland, Gaofeng Wang
Format: Article
Language:English
Published: Elsevier 2019-05-01
Series:EBioMedicine
Online Access:http://www.sciencedirect.com/science/article/pii/S2352396419302403

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http://www.sciencedirect.com/science/article/pii/S2352396419302403

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