Pepsin digest of wheat gliadin fraction increases production of IL-1β via TLR4/MyD88/TRIF/MAPK/NF-κB signaling pathway and an NLRP3 inflammasome activation.

Pepsin digest of wheat gliadin fraction increases production of IL-1β via TLR4/MyD88/TRIF/MAPK/NF-κB signaling pathway and an NLRP3 inflammasome activation.

Celiac disease (CD) is a gluten-responsive, chronic inflammatory enteropathy. IL-1 cytokine family members IL-1β and IL-18 have been associated with the inflammatory conditions in CD patients. However, the mechanisms of IL-1 molecule activation in CD have not yet been elucidated. We show in this stu...

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Bibliographic Details
Main Authors: Lenka Palová-Jelínková, Klára Dáňová, Hana Drašarová, Miloš Dvořák, David P Funda, Petra Fundová, Anna Kotrbová-Kozak, Marie Černá, Jana Kamanová, Stefan F Martin, Marina Freudenberg, Ludmila Tučková
Format: Article
Language:English
Published: Public Library of Science (PLoS) 2013-01-01
Series:PLoS ONE
Online Access:http://europepmc.org/articles/PMC3639175?pdf=render

Internet

http://europepmc.org/articles/PMC3639175?pdf=render

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