Comparison of reprogramming factor targets reveals both species-specific and conserved mechanisms in early iPSC reprogramming

Comparison of reprogramming factor targets reveals both species-specific and conserved mechanisms in early iPSC reprogramming

Abstract Background Both human and mouse fibroblasts can be reprogrammed to pluripotency with Oct4, Sox2, Klf4, and c-Myc (OSKM) transcription factors. While both systems generate pluripotency, human reprogramming takes considerably longer than mouse. Results To assess additional similarities and di...

Full description

Bibliographic Details
Main Authors: Kai Fu, Constantinos Chronis, Abdenour Soufi, Giancarlo Bonora, Miguel Edwards, Stephen T. Smale, Kenneth S. Zaret, Kathrin Plath, Matteo Pellegrini
Format: Article
Language:English
Published: BMC 2018-12-01
Series:BMC Genomics
Subjects:
Reprogramming
iPS cells
Comparative epigenomics
Online Access:http://link.springer.com/article/10.1186/s12864-018-5326-1

Internet

http://link.springer.com/article/10.1186/s12864-018-5326-1

Similar Items