P2Y12 receptor mediates microglial activation via RhoA/ROCK pathway in the trigeminal nucleus caudalis in a mouse model of chronic migraine

P2Y12 receptor mediates microglial activation via RhoA/ROCK pathway in the trigeminal nucleus caudalis in a mouse model of chronic migraine

Abstract Background Microglial activation contributes to the development of chronic migraine (CM). The P2Y12 receptor (P2Y12R), a metabolic purinoceptor that is expressed on microglia in the central nervous system (CNS), has been indicated to play a critical role in the pathogenesis of chronic pain....

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Bibliographic Details
Main Authors: Feng Jing, Yixin Zhang, Ting Long, Wei He, Guangcheng Qin, Dunke Zhang, Lixue Chen, Jiying Zhou
Format: Article
Language:English
Published: BMC 2019-11-01
Series:Journal of Neuroinflammation
Subjects:
P2Y12 receptor
Microglia
Chronic migraine
Trigeminal nucleus caudalis
Hyperalgesia
Nitroglycerin
Online Access:http://link.springer.com/article/10.1186/s12974-019-1603-4

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http://link.springer.com/article/10.1186/s12974-019-1603-4

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