SOX21 modulates SOX2-initiated differentiation of epithelial cells in the extrapulmonary airways

SOX21 modulates SOX2-initiated differentiation of epithelial cells in the extrapulmonary airways

SOX2 expression levels are crucial for the balance between maintenance and differentiation of airway progenitor cells during development and regeneration. Here, we describe patterning of the mouse proximal airway epithelium by SOX21, which coincides with high levels of SOX2 during development. Airwa...

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Bibliographic Details
Main Authors: Evelien Eenjes, Marjon Buscop-van Kempen, Anne Boerema-de Munck, Gabriela G Edel, Floor Benthem, Lisette de Kreij-de Bruin, Marco Schnater, Dick Tibboel, Jennifer Collins, Robbert J Rottier
Format: Article
Language:English
Published: eLife Sciences Publications Ltd 2021-07-01
Series:eLife
Subjects:
lung development
SOX2
SOX21
epithelial differentiation
regeneration
progenitor cells
Online Access:https://elifesciences.org/articles/57325

Internet

https://elifesciences.org/articles/57325

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