Phosphoproteomic Alterations of Ionotropic Glutamate Receptors in the Hippocampus of the Ts65Dn Mouse Model of Down Syndrome

Phosphoproteomic Alterations of Ionotropic Glutamate Receptors in the Hippocampus of the Ts65Dn Mouse Model of Down Syndrome

Down syndrome (DS), the main genetic cause of intellectual disability, is associated with an imbalance of excitatory/inhibitory neurotransmitter systems. The phenotypic assessment and pharmacotherapy interventions in DS murine models strongly pointed out glutamatergic neurotransmission alterations (...

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Bibliographic Details
Main Authors: Macarena Gómez de Salazar, Cristina Grau, Francisco Ciruela, Xavier Altafaj
Format: Article
Language:English
Published: Frontiers Media S.A. 2018-07-01
Series:Frontiers in Molecular Neuroscience
Subjects:
Down syndrome
ionotropic glutamate receptors
NMDA receptor
kinases
proteomics
phosphoproteomics
Online Access:https://www.frontiersin.org/article/10.3389/fnmol.2018.00226/full

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https://www.frontiersin.org/article/10.3389/fnmol.2018.00226/full

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