Microscale 3D Liver Bioreactor for In Vitro Hepatotoxicity Testing under Perfusion Conditions

Microscale 3D Liver Bioreactor for In Vitro Hepatotoxicity Testing under Perfusion Conditions

The accurate prediction of hepatotoxicity demands validated human in vitro models that can close the gap between preclinical animal studies and clinical trials. In this study we investigated the response of primary human liver cells to toxic drug exposure in a perfused microscale 3D liver bioreactor...

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Bibliographic Details
Main Authors: Nora Freyer, Selina Greuel, Fanny Knöspel, Florian Gerstmann, Lisa Storch, Georg Damm, Daniel Seehofer, Jennifer Foster Harris, Rashi Iyer, Frank Schubert, Katrin Zeilinger
Format: Article
Language:English
Published: MDPI AG 2018-03-01
Series:Bioengineering
Subjects:
microscale 3D liver bioreactor
in vitro perfusion
primary human liver cells
hepatotoxicity
acetaminophen
Online Access:http://www.mdpi.com/2306-5354/5/1/24

Internet

http://www.mdpi.com/2306-5354/5/1/24

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