Impaired CpG Demethylation in Common Variable Immunodeficiency Associates With B Cell Phenotype and Proliferation Rate

Impaired CpG Demethylation in Common Variable Immunodeficiency Associates With B Cell Phenotype and Proliferation Rate

Common Variable Immunodeficiency (CVID) is characterized by impaired antibody production and poor terminal differentiation of the B cell compartment, yet its pathogenesis is still poorly understood. We first reported the occurrence of epigenetic alterations in CVID by high-throughput methylation ana...

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Bibliographic Details
Main Authors: Lucía del Pino-Molina, Javier Rodríguez-Ubreva, Juan Torres Canizales, María Coronel-Díaz, Marta Kulis, José I. Martín-Subero, Mirjam van der Burg, Esteban Ballestar, Eduardo López-Granados
Format: Article
Language:English
Published: Frontiers Media S.A. 2019-04-01
Series:Frontiers in Immunology
Subjects:
common variable immunodeficiency
B cells
CpG
DNA methylation
B cell phenotype
proliferation rate
Online Access:https://www.frontiersin.org/article/10.3389/fimmu.2019.00878/full

Internet

https://www.frontiersin.org/article/10.3389/fimmu.2019.00878/full

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