Inhibiting Human Parainfluenza Virus Infection by Preactivating the Cell Entry Mechanism

Inhibiting Human Parainfluenza Virus Infection by Preactivating the Cell Entry Mechanism

Paramyxoviruses, including human parainfluenza virus type 3, are internalized into host cells by fusion between viral and target cell membranes. The receptor binding protein, hemagglutinin-neuraminidase (HN), and the fusion protein (F) facilitate viral fusion and entry into cells through a process i...

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Bibliographic Details
Main Authors: S. F. Bottom-Tanzer, K. Rybkina, J. N. Bell, C. A. Alabi, C. Mathieu, M. Lu, S. Biswas, M. Vasquez, M. Porotto, J. A. Melero, V. Más, A. Moscona
Format: Article
Language:English
Published: American Society for Microbiology 2019-02-01
Series:mBio
Subjects:
antiviral
conformational antibody
fusion activation
paramyxovirus
viral fusion
viral glycoprotein antibody
Online Access:https://doi.org/10.1128/mBio.02900-18

Internet

https://doi.org/10.1128/mBio.02900-18

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