Aging Reduces L-type Calcium Channel Current and the Vasodilatory Response of Small Mesenteric Arteries to Calcium Channel Blockers

Aging Reduces L-type Calcium Channel Current and the Vasodilatory Response of Small Mesenteric Arteries to Calcium Channel Blockers

Calcium channel blockers are widely used to treat cardiovascular disease (CVD) including hypertension. As aging is an independent risk factor for CVD, the use of calcium channel blockers increases with increasing age. Hence, this study was designed to evaluate the effect of aging on the sensitivity...

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Bibliographic Details
Main Authors: Sulayma A Albarwani, Fathi eMansour, Abdul Aleem eKhan, Intisar eAl-Lawati, Abdulla eAl-Kaabi, Al-Manar eAl-Busaidi, Safa eAl-Hadhrami, Isehaq eAl-Husseini, Sultan eAl-Siyabi, Musbah O Tanira
Format: Article
Language:English
Published: Frontiers Media S.A. 2016-05-01
Series:Frontiers in Physiology
Subjects:
Aging
Calcium Channel Blockers
Mesenteric Arteries
voltage gated calcium channels
F344 rats
Online Access:http://journal.frontiersin.org/Journal/10.3389/fphys.2016.00171/full

Internet

http://journal.frontiersin.org/Journal/10.3389/fphys.2016.00171/full

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