Psoriasis patients are enriched for genetic variants that protect against HIV-1 disease.

Psoriasis patients are enriched for genetic variants that protect against HIV-1 disease.

An important paradigm in evolutionary genetics is that of a delicate balance between genetic variants that favorably boost host control of infection but which may unfavorably increase susceptibility to autoimmune disease. Here, we investigated whether patients with psoriasis, a common immune-mediate...

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Bibliographic Details
Main Authors: Haoyan Chen, Genki Hayashi, Olivia Y Lai, Alexander Dilthey, Peter J Kuebler, Tami V Wong, Maureen P Martin, Marcelo A Fernandez Vina, Gil McVean, Matthias Wabl, Kieron S Leslie, Toby Maurer, Jeffrey N Martin, Steven G Deeks, Mary Carrington, Anne M Bowcock, Douglas F Nixon, Wilson Liao
Format: Article
Language:English
Published: Public Library of Science (PLoS) 2012-02-01
Series:PLoS Genetics
Online Access:http://europepmc.org/articles/PMC3343879?pdf=render

Internet

http://europepmc.org/articles/PMC3343879?pdf=render

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