High Levels of IL-18 and IFN-γ in Chronically Inflamed Tissue in Chronic Granulomatous Disease

High Levels of IL-18 and IFN-γ in Chronically Inflamed Tissue in Chronic Granulomatous Disease

Background: Chronic granulomatous disease (CGD) is caused by a malfunctioning nicotinamide adenine dinucleotide phosphate (NADPH) oxidase complex in phagocytes, leading to impaired bacterial and fungal killing and hyperinflammation.Objective: To characterize macrophage subsets and cytokine/chemokine...

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Bibliographic Details
Main Authors: Virginia Meda Spaccamela, Rocio G. Valencia, Oleksandr Pastukhov, Andrea Duppenthaler, Matthias S. Dettmer, Juliane Erb, Urs C. Steiner, Sven Hillinger, Carsten Speckmann, Stephan Ehl, Janine Reichenbach, Ulrich Siler
Format: Article
Language:English
Published: Frontiers Media S.A. 2019-10-01
Series:Frontiers in Immunology
Subjects:
chronic granulomatous disease
hyperinflammation
macrophage priming
macrophage re-priming
IL-18/IFN-γ loop
Online Access:https://www.frontiersin.org/article/10.3389/fimmu.2019.02236/full

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https://www.frontiersin.org/article/10.3389/fimmu.2019.02236/full

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