Senolytic Targeting of Bcl-2 Anti-Apoptotic Family Increases Cell Death in Irradiated Sarcoma Cells

Senolytic Targeting of Bcl-2 Anti-Apoptotic Family Increases Cell Death in Irradiated Sarcoma Cells

Radiotherapy (RT) is a key component of cancer treatment. Most of the time, radiation is given after surgery but for soft-tissue sarcomas (STS), pre-surgical radiation is commonly utilized. However, despite improvements in RT accuracy, the rate of local recurrence remains high and is the major cause...

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Bibliographic Details
Main Authors: Julie Lafontaine, Guillaume B. Cardin, Nicolas Malaquin, Jean-Sébastien Boisvert, Francis Rodier, Philip Wong
Format: Article
Language:English
Published: MDPI AG 2021-01-01
Series:Cancers
Subjects:
soft tissue sarcoma
undifferentiated pleomorphic sarcoma
ionizing radiation
pre-operative radiotherapy
senescence
senolytic
Online Access:https://www.mdpi.com/2072-6694/13/3/386

Internet

https://www.mdpi.com/2072-6694/13/3/386

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