Predicting the Functional Impact of CDH1 Missense Mutations in Hereditary Diffuse Gastric Cancer

Predicting the Functional Impact of CDH1 Missense Mutations in Hereditary Diffuse Gastric Cancer

The role of E-cadherin in Hereditary Diffuse Gastric Cancer (HDGC) is unequivocal. Germline alterations in its encoding gene (CDH1) are causative of HDGC and occur in about 40% of patients. Importantly, while in most cases CDH1 alterations result in the complete loss of E-cadherin associated with a...

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Bibliographic Details
Main Authors: Soraia Melo, Joana Figueiredo, Maria Sofia Fernandes, Margarida Gonçalves, Eurico Morais-de-Sá, João Miguel Sanches, Raquel Seruca
Format: Article
Language:English
Published: MDPI AG 2017-12-01
Series:International Journal of Molecular Sciences
Subjects:
Hereditary Diffuse Gastric Cancer
E-cadherin
CDH1 missense variants
functional characterization
diagnostic tools
Online Access:https://www.mdpi.com/1422-0067/18/12/2687

Internet

https://www.mdpi.com/1422-0067/18/12/2687

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