Reductions in midbrain GABAergic and dopamine neuron markers are linked in schizophrenia

Reductions in midbrain GABAergic and dopamine neuron markers are linked in schizophrenia

Abstract Reductions in the GABAergic neurotransmitter system exist across multiple brain regions in schizophrenia and encompass both pre- and postsynaptic components. While reduced midbrain GABAergic inhibitory neurotransmission may contribute to the hyperdopaminergia thought to underpin psychosis i...

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Bibliographic Details
Main Authors: Tertia D. Purves-Tyson, Amelia M. Brown, Christin Weissleder, Debora A. Rothmond, Cynthia Shannon Weickert
Format: Article
Language:English
Published: BMC 2021-06-01
Series:Molecular Brain
Subjects:
GABA
GABRA
GAD1
GAD65/67
Parvalbumin
Somatostatin
Online Access:https://doi.org/10.1186/s13041-021-00805-7

Internet

https://doi.org/10.1186/s13041-021-00805-7

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