Transcriptional down-regulation of ccr5 in a subset of HIV+ controllers and their family members

Transcriptional down-regulation of ccr5 in a subset of HIV+ controllers and their family members

HIV +Elite and Viremic controllers (EC/VCs) are able to control virus infection, perhaps because of host genetic determinants. We identified 16% (21 of 131) EC/VCs with CD4 +T cells with resistance specific to R5-tropic HIV, reversed after introduction of ccr5. R5 resistance was not observed in macr...

Full description

Bibliographic Details
Main Authors: Elena Gonzalo-Gil, Patrick B Rapuano, Uchenna Ikediobi, Rebecca Leibowitz, Sameet Mehta, Ayse K Coskun, J Zachary Porterfield, Teagan D Lampkin, Vincent C Marconi, David Rimland, Bruce D Walker, Steven Deeks, Richard E Sutton
Format: Article
Language:English
Published: eLife Sciences Publications Ltd 2019-04-01
Series:eLife
Subjects:
HIV
ccr5
transcription
elite controllers
viremic controllers
ccr2
Online Access:https://elifesciences.org/articles/44360

Internet

https://elifesciences.org/articles/44360

Similar Items