A Francisella tularensis Schu S4 purine auxotroph is highly attenuated in mice but offers limited protection against homologous intranasal challenge.

A Francisella tularensis Schu S4 purine auxotroph is highly attenuated in mice but offers limited protection against homologous intranasal challenge.

Francisella tularensis is a gram-negative coccobacillus that causes the febrile illness tularemia. Subspecies that are pathogenic for humans include those comprising the type A (subspecies tularensis) or type B (subspecies holarctica) biovars. An attenuated live vaccine strain (LVS) developed from a...

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Bibliographic Details
Main Authors: Roger D Pechous, Travis R McCarthy, Nrusingh P Mohapatra, Shilpa Soni, Renee M Penoske, Nita H Salzman, Dara W Frank, John S Gunn, Thomas C Zahrt
Format: Article
Language:English
Published: Public Library of Science (PLoS) 2008-06-01
Series:PLoS ONE
Online Access:http://europepmc.org/articles/PMC2429968?pdf=render

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http://europepmc.org/articles/PMC2429968?pdf=render

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