MutSα maintains the mismatch repair capability by inhibiting PCNA unloading

MutSα maintains the mismatch repair capability by inhibiting PCNA unloading

Eukaryotic mismatch repair (MMR) utilizes single-strand breaks as signals to target the strand to be repaired. DNA-bound PCNA is also presumed to direct MMR. The MMR capability must be limited to a post-replicative temporal window during which the signals are available. However, both identity of the...

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Bibliographic Details
Main Authors: Yoshitaka Kawasoe, Toshiki Tsurimoto, Takuro Nakagawa, Hisao Masukata, Tatsuro S Takahashi
Format: Article
Language:English
Published: eLife Sciences Publications Ltd 2016-07-01
Series:eLife
Subjects:
mismatch repair
proliferating cell nuclear antigen
DNA replication
Xenopus egg extract
MutSα
Online Access:https://elifesciences.org/articles/15155

Internet

https://elifesciences.org/articles/15155

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