MutSα maintains the mismatch repair capability by inhibiting PCNA unloading
Eukaryotic mismatch repair (MMR) utilizes single-strand breaks as signals to target the strand to be repaired. DNA-bound PCNA is also presumed to direct MMR. The MMR capability must be limited to a post-replicative temporal window during which the signals are available. However, both identity of the...
Main Authors: | Yoshitaka Kawasoe, Toshiki Tsurimoto, Takuro Nakagawa, Hisao Masukata, Tatsuro S Takahashi |
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Format: | Article |
Language: | English |
Published: |
eLife Sciences Publications Ltd
2016-07-01
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Series: | eLife |
Subjects: | |
Online Access: | https://elifesciences.org/articles/15155 |
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