Integrase-RNA interactions underscore the critical role of integrase in HIV-1 virion morphogenesis

Integrase-RNA interactions underscore the critical role of integrase in HIV-1 virion morphogenesis

A large number of human immunodeficiency virus 1 (HIV-1) integrase (IN) alterations, referred to as class II substitutions, exhibit pleiotropic effects during virus replication. However, the underlying mechanism for the class II phenotype is not known. Here we demonstrate that all tested class II IN...

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Bibliographic Details
Main Authors: Jennifer L Elliott, Jenna E Eschbach, Pratibha C Koneru, Wen Li, Maritza Puray-Chavez, Dana Townsend, Dana Q Lawson, Alan N Engelman, Mamuka Kvaratskhelia, Sebla B Kutluay
Format: Article
Language:English
Published: eLife Sciences Publications Ltd 2020-09-01
Series:eLife
Subjects:
HIV-1
Integrase
maturation
Integrase-RNA interactions
Online Access:https://elifesciences.org/articles/54311

Internet

https://elifesciences.org/articles/54311

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