Cell Metabolism Control Through O-GlcNAcylation of STAT5: A Full or Empty Fuel Tank Makes a Big Difference for Cancer Cell Growth and Survival

Cell Metabolism Control Through O-GlcNAcylation of STAT5: A Full or Empty Fuel Tank Makes a Big Difference for Cancer Cell Growth and Survival

O-GlcNAcylation is a post-translational modification that influences tyrosine phosphorylation in healthy and malignant cells. O-GlcNAc is a product of the hexosamine biosynthetic pathway, a side pathway of glucose metabolism. It is essential for cell survival and proper gene regulation, mirroring th...

Full description

Bibliographic Details
Main Authors: Manuel Rauth, Patricia Freund, Anna Orlova, Stefan Grünert, Nikola Tasic, Xiaonan Han, Hai-Bin Ruan, Heidi A. Neubauer, Richard Moriggl
Format: Article
Language:English
Published: MDPI AG 2019-02-01
Series:International Journal of Molecular Sciences
Subjects:
STAT5A
STAT5B
STAT3
JAK kinases
tyrosine phosphorylation
O-GlcNAcylation
O-GlcNAc transferase
O-GlcNAcase
Online Access:https://www.mdpi.com/1422-0067/20/5/1028

Internet

https://www.mdpi.com/1422-0067/20/5/1028

Similar Items