Chrysomycin A Attenuates Neuroinflammation by Down-Regulating NLRP3/Cleaved Caspase-1 Signaling Pathway in LPS-Stimulated Mice and BV2 Cells

Chrysomycin A Attenuates Neuroinflammation by Down-Regulating NLRP3/Cleaved Caspase-1 Signaling Pathway in LPS-Stimulated Mice and BV2 Cells

Chrysomycin A (Chr-A), an antibiotic chrysomycin, was discovered in 1955 and is used to treat cancer and tuberculosis. In the present study, the anti-neuroinflammatory effects and possible mechanism of Chr-A in BALB/c mice and in BV2 microglia cells stimulated by lipopolysaccharide (LPS) were invest...

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Bibliographic Details
Main Authors: Man Liu, Shan-Shan Zhang, Dong-Ni Liu, Ying-Lin Yang, Yue-Hua Wang, Guan-Hua Du
Format: Article
Language:English
Published: MDPI AG 2021-06-01
Series:International Journal of Molecular Sciences
Subjects:
Chrysomycin A
neuroinflammation
BV2 microglia cells
lipopolysaccharide (LPS)
Online Access:https://www.mdpi.com/1422-0067/22/13/6799

Internet

https://www.mdpi.com/1422-0067/22/13/6799

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