H5N1 and 1918 pandemic influenza virus infection results in early and excessive infiltration of macrophages and neutrophils in the lungs of mice.

Fatal human respiratory disease associated with the 1918 pandemic influenza virus and potentially pandemic H5N1 viruses is characterized by severe lung pathology, including pulmonary edema and extensive inflammatory infiltrate. Here, we quantified the cellular immune response to infection in the mou...

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Bibliographic Details
Main Authors: Lucy A Perrone, Julie K Plowden, Adolfo García-Sastre, Jacqueline M Katz, Terrence M Tumpey
Format: Article
Language:English
Published: Public Library of Science (PLoS) 2008-08-01
Series:PLoS Pathogens
Online Access:http://europepmc.org/articles/PMC2483250?pdf=render