Phenotypic and Functional Analyses Guiding Combination Immune Checkpoint Immunotherapeutic Strategies in HTLV-1 Infection

Phenotypic and Functional Analyses Guiding Combination Immune Checkpoint Immunotherapeutic Strategies in HTLV-1 Infection

Human T-cell lymphotropic virus type 1 (HTLV-1)-associated myelopathy/tropical spastic paraparesis (HAM/TSP) develops in 1–5% of HTLV-1-infected individuals. Previous studies by us and others have shown that the expression of negative immune checkpoint receptors (NCRs) is significantly increased on...

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Bibliographic Details
Main Authors: Danielle M. Clements, Brenndan Crumley, Glen M. Chew, Elijah Davis, Roberta Bruhn, Edward L. Murphy, Lishomwa C. Ndhlovu, Pooja Jain
Format: Article
Language:English
Published: Frontiers Media S.A. 2021-03-01
Series:Frontiers in Immunology
Subjects:
HTLV-1
HAM/TSP
PD-1
TIGIT
TIM-3
LAG-3
Online Access:https://www.frontiersin.org/articles/10.3389/fimmu.2021.608890/full

Internet

https://www.frontiersin.org/articles/10.3389/fimmu.2021.608890/full

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