Cardiac-Specific Overexpression of Catalytically Inactive Corin Reduces Edema, Contractile Dysfunction, and Death in Mice with Dilated Cardiomyopathy

Cardiac-Specific Overexpression of Catalytically Inactive Corin Reduces Edema, Contractile Dysfunction, and Death in Mice with Dilated Cardiomyopathy

Humans with dilated cardiomyopathy (DCM) and heart failure (HF) develop low levels of corin, a multi-domain, cardiac-selective serine protease involved in natriuretic peptide cleavage and sodium and water regulation. However, experimental restoration of corin levels markedly attenuates HF progressio...

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Bibliographic Details
Main Authors: Ranjana Tripathi, Ryan D. Sullivan, Tai-Hwang M. Fan, Aiilyan K. Houng, Radhika M. Mehta, Guy L. Reed, Inna P. Gladysheva
Format: Article
Language:English
Published: MDPI AG 2019-12-01
Series:International Journal of Molecular Sciences
Subjects:
corin
dilated cardiomyopathy
heart failure
edema
Online Access:https://www.mdpi.com/1422-0067/21/1/203

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https://www.mdpi.com/1422-0067/21/1/203

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