The origins of specificity in polyketide synthase protein interactions.

Polyketides, a diverse group of heteropolymers with antibiotic and antitumor properties, are assembled in bacteria by multiprotein chains of modular polyketide synthase (PKS) proteins. Specific protein-protein interactions determine the order of proteins within a multiprotein chain, and thereby the...

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Bibliographic Details
Main Authors: Mukund Thattai, Yoram Burak, Boris I Shraiman
Format: Article
Language:English
Published: Public Library of Science (PLoS) 2007-09-01
Series:PLoS Computational Biology
Online Access:http://europepmc.org/articles/PMC1994986?pdf=render