A Reassessment of the in vitro total protein content determination (TPC) with SIRC and 3T3 cells for the evaluation of the ocular irritation potential of shampoos: comparison with the in vivo Draize rabbit test

A Reassessment of the in vitro total protein content determination (TPC) with SIRC and 3T3 cells for the evaluation of the ocular irritation potential of shampoos: comparison with the in vivo Draize rabbit test

The aim of this work was to determine the correlation between results obtained from the Draize test and from the Total Protein Content Determination (TPC) to assess the ocular irritancy potential of 20 shampoos. For TPC, two established cell lines (SIRC and 3T3) were used. The concentration that ind...

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Bibliographic Details
Main Authors: Rodrigo Netto Costa, Clarice Lima do Canto Abreu, Rosaura Farias Presgrave, Eloisa Nunes Alves, Octavio Augusto França Presgrave, Isabella Fernandes Delgado
Format: Article
Language:English
Published: Instituto de Tecnologia do Paraná (Tecpar) 2011-12-01
Series:Brazilian Archives of Biology and Technology
Subjects:
Draize test
ocular irritation
TPC
shampoos
SIRC
3T3
Online Access:http://www.scielo.br/scielo.php?script=sci_arttext&pid=S1516-89132011000600008

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http://www.scielo.br/scielo.php?script=sci_arttext&pid=S1516-89132011000600008

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