Patient-derived pancreas-on-a-chip to model cystic fibrosis-related disorders

Patient-derived pancreas-on-a-chip to model cystic fibrosis-related disorders

Defective CFTR protein, responsible for Cystic Fibrosis (CF), is highly expressed in pancreatic ductal epithelial cells (PDECs) but their impact on insulin secreting pancreatic islets is not fully understood. Here the authors develop a non-CF and CF patient derived pancreas-on-a-chip model to study...

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Bibliographic Details
Main Authors: Kyu Shik Mun, Kavisha Arora, Yunjie Huang, Fanmuyi Yang, Sunitha Yarlagadda, Yashaswini Ramananda, Maisam Abu-El-Haija, Joseph J. Palermo, Balamurugan N. Appakalai, Jaimie D. Nathan, Anjaparavanda P. Naren
Format: Article
Language:English
Published: Nature Publishing Group 2019-07-01
Series:Nature Communications
Online Access:https://doi.org/10.1038/s41467-019-11178-w

Internet

https://doi.org/10.1038/s41467-019-11178-w

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