Patient-derived pancreas-on-a-chip to model cystic fibrosis-related disorders
Defective CFTR protein, responsible for Cystic Fibrosis (CF), is highly expressed in pancreatic ductal epithelial cells (PDECs) but their impact on insulin secreting pancreatic islets is not fully understood. Here the authors develop a non-CF and CF patient derived pancreas-on-a-chip model to study...
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Bibliographic Details
Main Authors: |
Kyu Shik Mun,
Kavisha Arora,
Yunjie Huang,
Fanmuyi Yang,
Sunitha Yarlagadda,
Yashaswini Ramananda,
Maisam Abu-El-Haija,
Joseph J. Palermo,
Balamurugan N. Appakalai,
Jaimie D. Nathan,
Anjaparavanda P. Naren |
Format: | Article
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Language: | English |
Published: |
Nature Publishing Group
2019-07-01
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Series: | Nature Communications
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Online Access: | https://doi.org/10.1038/s41467-019-11178-w
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