Patient-derived pancreas-on-a-chip to model cystic fibrosis-related disorders

Defective CFTR protein, responsible for Cystic Fibrosis (CF), is highly expressed in pancreatic ductal epithelial cells (PDECs) but their impact on insulin secreting pancreatic islets is not fully understood. Here the authors develop a non-CF and CF patient derived pancreas-on-a-chip model to study...

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Main Authors:	Kyu Shik Mun, Kavisha Arora, Yunjie Huang, Fanmuyi Yang, Sunitha Yarlagadda, Yashaswini Ramananda, Maisam Abu-El-Haija, Joseph J. Palermo, Balamurugan N. Appakalai, Jaimie D. Nathan, Anjaparavanda P. Naren
Format:	Article
Language:	English
Published:	Nature Publishing Group 2019-07-01
Series:	Nature Communications
Online Access:	https://doi.org/10.1038/s41467-019-11178-w

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spelling	doaj-fc92be52f03349bab8a0daee67da4a272021-05-11T12:28:59ZengNature Publishing GroupNature Communications2041-17232019-07-0110111210.1038/s41467-019-11178-wPatient-derived pancreas-on-a-chip to model cystic fibrosis-related disordersKyu Shik Mun0Kavisha Arora1Yunjie Huang2Fanmuyi Yang3Sunitha Yarlagadda4Yashaswini Ramananda5Maisam Abu-El-Haija6Joseph J. Palermo7Balamurugan N. Appakalai8Jaimie D. Nathan9Anjaparavanda P. Naren10Department of Pediatrics, Division of Pulmonary Medicine, Cincinnati Children’s Hospital Medical CenterDepartment of Pediatrics, Division of Pulmonary Medicine, Cincinnati Children’s Hospital Medical CenterDepartment of Pediatrics, Division of Pulmonary Medicine, Cincinnati Children’s Hospital Medical CenterDepartment of Pediatrics, Division of Pulmonary Medicine, Cincinnati Children’s Hospital Medical CenterDepartment of Pediatrics, Division of Pulmonary Medicine, Cincinnati Children’s Hospital Medical CenterDepartment of Pediatrics, Division of Pulmonary Medicine, Cincinnati Children’s Hospital Medical CenterDivision of Pediatric Gastroenterology, Hepatology and Nutrition, Cincinnati Children’s Hospital Medical CenterDivision of Pediatric Gastroenterology, Hepatology and Nutrition, Cincinnati Children’s Hospital Medical CenterDepartment of Surgery, Center for Cellular Transplantation, Cardiovascular Innovation Institute, University of LouisvilleDivision of Pediatric General and Thoracic Surgery, Cincinnati Children’s Hospital Medical CenterDepartment of Pediatrics, Division of Pulmonary Medicine, Cincinnati Children’s Hospital Medical CenterDefective CFTR protein, responsible for Cystic Fibrosis (CF), is highly expressed in pancreatic ductal epithelial cells (PDECs) but their impact on insulin secreting pancreatic islets is not fully understood. Here the authors develop a non-CF and CF patient derived pancreas-on-a-chip model to study how CF affects insulin secretion.https://doi.org/10.1038/s41467-019-11178-w
collection	DOAJ
language	English
format	Article
sources	DOAJ
author	Kyu Shik Mun Kavisha Arora Yunjie Huang Fanmuyi Yang Sunitha Yarlagadda Yashaswini Ramananda Maisam Abu-El-Haija Joseph J. Palermo Balamurugan N. Appakalai Jaimie D. Nathan Anjaparavanda P. Naren
spellingShingle	Kyu Shik Mun Kavisha Arora Yunjie Huang Fanmuyi Yang Sunitha Yarlagadda Yashaswini Ramananda Maisam Abu-El-Haija Joseph J. Palermo Balamurugan N. Appakalai Jaimie D. Nathan Anjaparavanda P. Naren Patient-derived pancreas-on-a-chip to model cystic fibrosis-related disorders Nature Communications
author_facet	Kyu Shik Mun Kavisha Arora Yunjie Huang Fanmuyi Yang Sunitha Yarlagadda Yashaswini Ramananda Maisam Abu-El-Haija Joseph J. Palermo Balamurugan N. Appakalai Jaimie D. Nathan Anjaparavanda P. Naren
author_sort	Kyu Shik Mun
title	Patient-derived pancreas-on-a-chip to model cystic fibrosis-related disorders
title_short	Patient-derived pancreas-on-a-chip to model cystic fibrosis-related disorders
title_full	Patient-derived pancreas-on-a-chip to model cystic fibrosis-related disorders
title_fullStr	Patient-derived pancreas-on-a-chip to model cystic fibrosis-related disorders
title_full_unstemmed	Patient-derived pancreas-on-a-chip to model cystic fibrosis-related disorders
title_sort	patient-derived pancreas-on-a-chip to model cystic fibrosis-related disorders
publisher	Nature Publishing Group
series	Nature Communications
issn	2041-1723
publishDate	2019-07-01
description	Defective CFTR protein, responsible for Cystic Fibrosis (CF), is highly expressed in pancreatic ductal epithelial cells (PDECs) but their impact on insulin secreting pancreatic islets is not fully understood. Here the authors develop a non-CF and CF patient derived pancreas-on-a-chip model to study how CF affects insulin secretion.
url	https://doi.org/10.1038/s41467-019-11178-w
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Patient-derived pancreas-on-a-chip to model cystic fibrosis-related disorders

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