A novel culture method that sustains ERα signaling in human breast cancer tissue microstructures

A novel culture method that sustains ERα signaling in human breast cancer tissue microstructures

Abstract Background Estrogen receptor α (ERα) signaling is a defining and driving event in most breast cancers; ERα is detected in malignant epithelial cells of 75% of all breast cancers (classified as ER-positive breast cancer) and, in these cases, ERα targeting is the main therapeutic strategy. Ho...

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Bibliographic Details
Main Authors: Ana Luísa Cartaxo, Marta F. Estrada, Giacomo Domenici, Ruben Roque, Fernanda Silva, Emilio J. Gualda, Pablo Loza-Alvarez, George Sflomos, Cathrin Brisken, Paula M. Alves, Saudade André, Catarina Brito
Format: Article
Language:English
Published: BMC 2020-08-01
Series:Journal of Experimental & Clinical Cancer Research
Subjects:
Cancer
Patient-derived cancer models
17-β-estradiol
Estrogen receptor alpha
Fulvestrant
Encapsulation
Online Access:http://link.springer.com/article/10.1186/s13046-020-01653-4

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http://link.springer.com/article/10.1186/s13046-020-01653-4

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