Strategy to prevent epitope masking in CAR.CD19+ B-cell leukemia blasts

Strategy to prevent epitope masking in CAR.CD19+ B-cell leukemia blasts

Background Methods We evaluated the impact of a high percentage of leukemia blast contamination in patient-derived starting material (SM) on CAR T-cell drug product (DP) manufacturing. In vitro as well as in vivo models were employed to identify characteristics of the construct associated with bette...

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Bibliographic Details
Main Authors: Marco Ruella, Valentina Bertaina, Franco Locatelli, Antonio Camera, Biagio De Angelis, Francesca Del Bufalo, Concetta Quintarelli, Pietro Merli, Marika Guercio, Simona Manni, Iolanda Boffa, Matilde Sinibaldi, Stefano Di Cecca, Simona Caruso, Zeinab Abbaszadeh, Biancamaria Cembrola, Roselia Ciccone, Alberto Orfao, Lourdes Martin-Martin, Sara Gutierrez-Herrero, Maria Herrero-Garcia, Gianni Cazzaniga, Vittorio Nunes, Simona Songia, Paolo Marcatili, Frederikke I Marin, Luciana Vinti, Mattia Algeri
Format: Article
Language:English
Published: BMJ Publishing Group 2021-06-01
Series:Journal for ImmunoTherapy of Cancer
Online Access:https://jitc.bmj.com/content/9/6/e001514.full

Internet

https://jitc.bmj.com/content/9/6/e001514.full

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