Mechanism of β-actin mRNA Recognition by ZBP1

Mechanism of β-actin mRNA Recognition by ZBP1

Zipcode binding protein 1 (ZBP1) is an oncofetal RNA-binding protein that mediates the transport and local translation of β-actin mRNA by the KH3-KH4 di-domain, which is essential for neuronal development. The high-resolution structures of KH3-KH4 with their respective target sequences show that KH4...

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Bibliographic Details
Main Authors: Giuseppe Nicastro, Adela M. Candel, Michael Uhl, Alain Oregioni, David Hollingworth, Rolf Backofen, Stephen R. Martin, Andres Ramos
Format: Article
Language:English
Published: Elsevier 2017-01-01
Series:Cell Reports
Subjects:
protein-RNA interactions
NMR
binding mechanism
neuronal mRNA granules
neuronal development
mRNA local translation
ZBP1
IMP1
Online Access:http://www.sciencedirect.com/science/article/pii/S2211124717300013

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http://www.sciencedirect.com/science/article/pii/S2211124717300013

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