N-Cadherin-Mediated Activation of PI3K/Akt-GSK-3β Signaling Attenuates Nucleus Pulposus Cell Apoptosis Under High-Magnitude Compression

N-Cadherin-Mediated Activation of PI3K/Akt-GSK-3β Signaling Attenuates Nucleus Pulposus Cell Apoptosis Under High-Magnitude Compression

Background/Aims: Mechanical overloading-induced nucleus pulposus (NP) apoptosis plays an important role in the pathogenesis of intervertebral disc degeneration. N-cadherin (N-CDH)-mediated signaling preserves normal NP cell phenotype. This study aims to investigate the effects of N-CDH on NP cell ap...

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Bibliographic Details
Main Authors: Pei Li, Zherui Liang, Gang Hou, Lei Song, Ruijie Zhang, Yibo Gan, Chengmin Zhang, Yichun Xu, Qiang Zhou
Format: Article
Language:English
Published: Cell Physiol Biochem Press GmbH & Co KG 2017-11-01
Series:Cellular Physiology and Biochemistry
Subjects:
Compression
Apoptosis
Nucleus pulposus cell
PI3K/Akt
N-cadherin
Online Access:https://www.karger.com/Article/FullText/484649

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https://www.karger.com/Article/FullText/484649

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